The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. A considerable and growing number of aquaporin crystal structures for the rational design of inhibitory molecules ii. Elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments iii. Comprehensive data on aquaporin immunohistochemistry iv. Aquaporin knockout animals for physiological studies and v. Assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines.
The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function...show more
