The genus borrelia in the spirochete phylum is not closely related to any other bacteria and has a highly unusual genome composed of a linear chromosome and multiple circular and linear plasmids that appear to be in a constant state of rearrangement recombination and deletion. The determination of the genome sequence of borrelia strains has facilitated tremendous advances in understanding this genus at the molecular and cellular level as well as the pathogenesis of lyme disease and relapsing fever. In recent years there has been an explosion of new insights into the molecular biology genetics physiology and ecology of borrelia and its tick vertebrate life cycle. This research is of particular importance as the incidence of lyme borreliosis continues to increase. Written by renowned scientists who have made seminal contributions to the field this book is a comprehensive guide to the pathogenic borrelia providing researchers advanced students clinicians and other professionals with an encyclopedic overview of the molecular biology of this important genus and the pathogenesis of diseases. Leading authorities have made contributions on topics such as borrelia genomics dna replication gene regulation transcriptomics proteomics metabolism and physiology cellular structure motility and chemotaxis genetic manipulation evolutionary genetics ecology tick interactions lyme disease and relapsing fever pathogenesis animal models host response detection and vaccines. The volume is esse...
Brand: Caister Academic Press
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