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Have you ever reached for a tissue and felt like you were rubbing sandpaper on your nose? Small everyday items, like facial tissues, make a surprisingly big difference when you’re battling a cold, dealing with allergies, or just trying to keep your home feeling cozy. The right tissue can feel like a warm hug—soft, strong, and sometimes even soothing thanks to added lotion. In this guide I’ll walk you through where to buy the best facial tissues in the US, highlight popular products and stores, and share smart tips for choosing the tissue that fits your needs and budget.
Walmart is a go-to for many because it blends low prices with a wide assortment. You’ll commonly find Kleenex Trusted Care 2-ply or Kleenex Original multi-packs, as well as brand options like Puffs Ultra Soft 2-ply 4-pack. Walmart also stocks value and private-label choices such as Perk Ultra Soft Standard Tissue 2-ply in multi-pack formats. If you want dependable quality without paying a premium, Walmart is a reliable stop—especially when you’re buying enough boxes to keep every room stocked.
Target mixes national brands with its Up&Up line, which often mirrors the softness and strength of name-brand tissues at a lower price. If aesthetics matter—think cute boxes for the guest bathroom—Target tends to have trendier packaging and seasonal prints. They also rotate specialty items like lotion-infused tissues and limited-edition designs, so if you’re in the mood to refresh your cupboards or buy a pretty pack for visitors, Target offers a pleasant shopping experience.
Buying tissues in bulk at Costco is like filling a pantry for winter: it feels reassuring and cost-effective. If you have a household of three or more, or if you prefer fewer shopping trips, multi-pack cases from Costco can bring the per-box cost way down. Keep in mind that bulk is best when storage space isn’t a problem and the brand meets your comfort standards—some warehouse packs focus on quantity over premium softness. Still, for sheer value-per-sheet, Costco is tough to beat.
Amazon advantage is convenience. You can compare Kleenex, Puffs, and store brands in minutes, read reviews, and set up Subscribe & Save so boxes appear on your doorstep on a regular schedule. That hands-off approach is perfect when you don’t want to risk running out during peak allergy season. Shipping options and frequent deals can make Amazon especially attractive if you don’t live near big-box stores or want to try unfamiliar brands without a special trip.
Pharmacies like Walgreens and CVS shine for convenience: they’re everywhere, and they carry single boxes and small multipacks that are perfect for travel, work desks, or grabbing mid-illness. Prices can be higher per box, but these stores often run promotions or accept digital coupons that narrow the gap. If you need tissues now and don’t want to wait for bulk delivery, pharmacies are the fast answer.
Dollar stores are tempting because the price point is unbeatable for quick needs. You’ll find generic facial tissues that do the job for seasonal sniffles or craft projects. Keep realistic expectations: dollar-store tissues often trade softness and sheet count for low cost. They’re perfect in a pinch or for non-sensitive uses, but if you have frequent colds or sensitive skin, you may want to choose higher-quality options for everyday use.
Choosing a tissue isn’t just picking a pretty box—there are practical differences. "Ply" refers to the number of layers; two-ply is common and balances softness with durability, while three-ply adds cushion and strength. Lotion or aloe-infused tissues are gentler on sore noses, especially during a long cold. Softness often comes from the fiber blend and manufacturing process; higher-priced brands usually invest more in feel. Consider how often you use tissues, whether you have sensitive skin, and whether you want robust sheets for makeup removal or delicate ones for nose care.
If you’ve ever had a cold that turned your nose into raw tissue, lotion tissues feel like a small miracle. They reduce friction and irritation, making repeated use less painful. Regular tissues are fine for everyday spills, makeup, and occasional sniffles. But when colds linger, or you have chronic allergies, a box of lotion-infused tissues can be kinder to your skin and might reduce the need for extra balm or ointment. Just be aware some lotion tissues can leave a faint residue—test one if you’re concerned about sensitivity.
Want to be kind to the planet but not your nose? Look for recycled-content tissues or those with FSC (Forest Stewardship Council) certification. Many mainstream brands now offer recycled or sustainably sourced lines that aim to maintain softness. Recycled tissues can feel a touch different than virgin-fiber tissues, but recent advances have narrowed the gap. If sustainability is a priority, check labels for percentage recycled fiber and certifications; buying larger packs can also lower overall environmental cost by reducing packaging waste per sheet.
Kleenex is often the household name for a reason: consistent softness, a wide range from budget to premium lines, and easy-to-find packs across retailers. Puffs stands out for their lotion-infused and ultra-soft variants aimed at sensitive skin. Perk and store brands—found at retailers like Walmart and Target—focus on value, giving you reasonable softness at a lower price. Bottom line: pick Kleenex or Puffs when you want maximum comfort, and opt for Perk or Up&Up for everyday savings.
Want to keep your tissues stocked without paying top dollar? Watch sale cycles—big-box stores and pharmacies run periodic discounts on household paper products, and subscribing to retailer emails often nets first-time coupons. Stack manufacturer coupons with store deals when possible, and consider Subscribe & Save on Amazon for steady discounts. Also, buying off-season (after cold and allergy peaks) can lead to better prices. When possible, calculate cost per sheet to compare true value across brands and pack sizes.
Keep bulk boxes in a dry spot away from heavy items that can crush them—closets or a pantry shelf work well. Single boxes look great on nightstands, desks, and bathroom counters; choose travel packs for purses or cars. For allergy season, put an extra box in commonly used rooms so you never have to wander the house searching for a tissue. If you like your tissues to stay soft and dust-free, store unopened boxes in their packaging until you need them.
Specialty tissues—like scented, hypoallergenic, or decorative printed boxes—are usually available at Target, Amazon, Walmart, and some pharmacies. Amazon and larger retailers have the broadest selection, while Target tends to offer seasonal designs and pretty patterns for living spaces or gifts. If you need medical-grade hypoallergenic tissues, check pharmacies or online specialty retailers that focus on sensitive-skin products.
Picking the right facial tissue comes down to matching comfort, cost, and convenience to your lifestyle. Walmart and Target give you a balance of value and choices, Costco and Amazon deliver bulk and subscription convenience, while pharmacies and dollar stores fill quick or budget needs. Brands like Kleenex and Puffs offer consistent softness and lotion options, and store brands shine when you want to save. With a few smart shopping habits—watching sales, comparing cost-per-sheet, and trying lotion-infused options for colds—you can keep your home stocked with tissues that feel good and make sniffles a little more bearable.
