Glycon-x - 15mg

Compound class and structure glycon x is a synthetic 39-amino-acid peptide in the incretin-mimetic class of laboratory research materials. Its backbone follows the glucagon superfamily architecture shared by glucagon-like peptide-1 glp-1 and glucose-dependent insulinotropic polypeptide gip , with substitutions and a lipidation handle that support extended plasma residence in rodent work and stability against dipeptidyl peptidase-4 cleavage at the n-terminus. The material is supplied as a sterile-filtered, lyophilised white powder sealed under vacuum in glass vials, offered in 15mg, 30mg and 60mg fills. Receptor pharmacology and signalling in cell-based characterisation, glycon x behaves as a dual agonist at the glp-1 receptor glp-1r and the gip receptor gipr , two class b1 g-protein-coupled receptors. Engagement of either receptor couples principally to g s, elevating intracellular cyclic amp and activating protein kinase a together with the epac2 rap1 axis. Secondary readouts include -arrestin-1 2 recruitment, receptor internalisation and recycling kinetics, and erk1 2 phosphorylation. Because one molecule addresses two receptor populations, investigators use glycon x to interrogate potency ratios ec50 comparisons across glp-1r and gipr , signal bias between camp and arrestin arms, cross-desensitisation, and whether combined incretin input behaves additively or synergistically relative to single-receptor ligands. Research areas and measured endpoints insulin-secretion dy... Brand: Real Peptides

Compound class and structure glycon x is a synthetic 39-amino-acid peptide in the incretin-mimetic class of laboratory research materials. Its backbone follows the glucagon superfamily